Rabbit antibody to 5HT4 R

FUNCTION: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Subcellular location: Cell membrane; Multi-pass membrane protein. Endosome. Note: Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
Tissue specificity: Isoform 5-HT4(A) is expressed in ileum, brain, and atrium, but not in the ventricle.

IHC, WB. A dilution of 1: 1000 is recommended for IHC-P and 1:2000 for WB. The optimal dilution should be determined by the end user. Not yet tested in other applications.

12 months after reconstitution

1. Blondel O, et al. J. Neurochem. 70:2252-2261(1998)
2. Claeysen S, et al. NeuroReport 8:3189-3195(1997)

A synthetic peptide from human 5HT4 R conjugated to blue carrier protein was used as the antigen.

http://www.uniprot.org/uniprot/Q13639
http://www.uniprot.org/uniprot/P97288
http://www.uniprot.org/uniprot/F7FEE7

Polyclonal

Lyophilised