Rabbit antibody to TrkB

FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user.

12 months after reconstitution

1. Klein R, et al. EMBO J. 8:3701-3709(1989).

A synthetic peptide from human TrkB conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

http://ca.expasy.org/uniprot/P15209
http://ca.expasy.org/uniprot/Q63604
http://www.uniprot.org/uniprot/Q16620

Polyclonal

Lyophilised