FADD Antibody, KO Validated

blue ice or room temperature

Observed: 28kDa

The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.

Antibody is Knockout validated.

Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1).

Fas (TNFRSF6)-associated via death domain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.