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COPS2 Antibody

COPS2 Antibody

Item no.	PRS-25-187-100ul
Manufacturer	ProSci
Amount	100 ul
Category	Antibodies Cell Biology Cell Status Western Blot ELISA Senescence Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Leal, J.F., (2008) Oncogene 27 (14), 1961-1970.
NCBI	COPS2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	COPS2,ALIEN,CSN2,SGN2,TRIP15
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	For short periods of storage (days) store at 4˚ C. For longer periods of storage, store COPS2 antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.
Molecular Weight	52 kDa
Manufacturer - Research Area	Transcription , Cancer , Signal Transduction
Background	COPS2 is an essential component of the COP9 signalosome complex (CSN). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. COPS2 is involved in early stage of neuronal differentiation via its interaction with NIF3L1.
By Type	Transcription, Cancer, Signal Transduction
Modifications	None
Protein Gi #	4759264
Purification	Antibody is purified by peptide affinity chromatography method.
Positive Control 1	PRS-1201-0.1mg
Concentration	batch dependent
Buffer	Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Application Note	COPS2 antibody can be used for detection of COPS2 by ELISA at 1:2500. COPS2 antibody can be used for detection of COPS2 by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50, 000 - 100, 000.
Immunogen	Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human COPS2.
Clonality	Polyclonal
NCBI Official Name	COP9 signalosome subunit 2
NCBI Organism	Homo sapiens
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 11/6/2025

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