SNCA Antibody [2B2D1 / 2B2A11]

Primary Antibodies

SNCA monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Alpha-synuclein (SNCA), with 140-amino acid protein (about 15 kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

None

batch dependent

Western Blot:1:500 - 1:2, 000
IHC(P):1:500 - 1:2, 000
IHC(F):1:500 - 1:2, 000
ELISA:Propose dilution 1:10, 000
Determining optimal working dilutions by titration test.

Monoclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.