DC-SIGN Antibody

Primary Antibodies

Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209, is part of the Lectin family of proteins. DC-SIGN is part of the innate immune response via its modulation of Toll-like Receptors. It is present on the surface of macrophages and dendritic cells and binds mannose carbohydrates, a class of PAMPS found on bacteria, fungi and viruses. PAMP stimulated DC-SIGN activates the Raf kinases Raf-1 and B-Raf. Raf-1 phosphorylates Ser276 of NF-kB p65 which serves as a binding site for histone acetyltransferases CREB-binding protein (CBP) and p300. Acetylation of NF-kB p65 leads to enhanced and prolonged anti-inflammatory cytokine IL-10 production.

None

0.5 mg/mL

Western blot: 2-5 ug/ml
Provided assay concentrations are suggestions only, DC-SIGN antibody titration may be required for optimal results.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher