Viperin Antibody

Primary Antibodies

Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

Viral infection induces the interferon (IFN) response which triggers the production of an array of anti-viral proteins. Viperin (Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible) is expressed in response to IFN-b binding to the IFN receptor, inducing the formation of the IFN-stimulated gene factor 3 complex which then binds to the Viperin promoter. It inhibits many DNA and RNA viruses through a diverse range of mechanisms and is involved in the PRR-mediated innate immune response. Viperin has been shown to be produced in response to TLR3 and TLR4 activation, but not TLR2 and TLR5. It may be involved in the TLR7 and TLR9-induced production of type I IFN by plasmacytoid dendritic cells (pDCs).

None

0.5 mg/mL

Western blot: 3-6 ug/ml
Provided assay concentrations are suggestions only, Viperin antibody titration may be required for optimal results.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher