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EGF Receptor Antibody [B1D8]

EGF Receptor Antibody [B1D8]

Item no.	PRS-33-120-100ug
Manufacturer	ProSci
Amount	100 ug
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Leukemia Flow Cytometry Immunoprecipitation Primary Antibodies By Organ Lung Cancer Bladder Cancer Colorectal Cancer Breast Cancer Testicular & Prostate Cancer Gallbladder Cancer Gastric Cancer Pancreatic Cancer Thyroid Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	FC, IP
Clone	B1D8
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Conjugate/Tag	Unconjugated
NCBI	EGF R
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Epidermal growth factor receptor,Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1,EGFR,ERBB,ERBB1,HER1
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Applications	Flow, IP, Inhibition Assay
Shipping Temperature	Blue Ice
Storage Conditions	Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Manufacturer - Research Area	Cancer, Signal Transduction
Background	This antibody reacts with the extracellular domain of EGF receptor and blocks the EGF/TGFa induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGF receptor. EGFR is type I receptor tyrosine kinase with sequence homology to ErbB2, -3 -4 or HER2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.
By Type	Cancer, Signal Transduction
Modifications	None
Purification	Protein G purified monoclonal antibody
Concentration	0.2 mg/mL
Buffer	PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Application Note	Functional Activity (Inhibition): antibody blocks EGF receptor activation inhibits A431 cell proliferation arrests tumor growth in vivo affinity purification IP: 1-2µg/500ug protein lysate Flow Cytometry: 0.5-1 ug/million cells The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the antibody to be titered up or down for optimal performance.
Manufacturer - Specificity	Does not react with mouse and rat
Immunogen	Microsomes from A431 cells were used as the immunogen for this antibody.
Clonality	Monoclonal
NCBI Official Name	epidermal growth factor receptor
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 12/4/2025

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