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Gamma Catenin Antibody [CTNG/1664]

Gamma Catenin Antibody [CTNG/1664]

Item no.	PRS-33-610-100ug
Manufacturer	ProSci
Amount	100 ug
Category	Antibodies Cell Biology Cytoskeleton Flow Cytometry Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies Intermediate filaments
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, FC, IF, IHC-P
Clone	CTNG/1664
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Conjugate/Tag	Unconjugated
NCBI	JUP
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Junction plakoglobin,Catenin gamma,Desmoplakin III,Desmoplakin-3,JUP,CTNNG,DP3
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.
Manufacturer - Research Area	Signal Transduction
Background	Plakoglobin, also known as junction plakoglobin or gamma Catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to beta-catenin. It is a cytoplasmic component of desmosomes and adherens junctions structures located within intercalated discs of cardiac muscle that function to anchor sarcomeres and join adjacent cells in cardiac muscle. Mutations in Gamma Catenin are associated with arrhythmogenic right ventricular dysplasia and Pemphigus vulgaris. Gamma Catenin is a major cytoplasmic component of both desmosomes and adherens junctions, and is the only known constituent common to submembranous plaques in both of these structures, which are located at the intercalated disc (ICD) of cardiomyocytes. It links cadherins to the actin cytoskeleton. Gamma Catenin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble desmosomes. [Wiki]
By Type	Signal Transduction
Modifications	None
Purification	Protein G affinity chromatography
Concentration	0.2 mg/mL
Buffer	PBS with 0.1 mg/ml BSA and 0.05% sodium azide
Application Note	Immunofluorescence: 1-2 ug/ml WB: 0.5-1 ug/ml Flow Cytometry: 0.5-1ug/10e6 cells in 0.1ml IHC (FFPE): 0.1-0.2 ug/ml The stated application concentrations are suggested starting amounts. Titration of the Gamma Catenin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Immunogen	Recombinant human protein was used as the immunogen for the Gamma Catenin antibody.
Clonality	Monoclonal
NCBI Official Name	junction plakoglobin
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ug

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Delivery expected until 12/4/2025

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