DC-SIGN Antibody [C209/1781]

Primary Antibodies

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

DC-SIGN / CD209 is a transmembrane receptor that is expressed on the surface of dendritic cells and macrophages. It is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization, which allows the receptor to bind multivalent ligands with high avidity.

None

0.2 mg/mL

IF: 1-2 ug/ml
Flow Cytometry: 0.5-1 ug/million cells in 0.1ml
IHC (FFPE): 0.5-1 ug/ml for 30 min at RT
Titering of the DC-SIGN antibody may be required for optimal performance.

Monoclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher