Recombinant CD8 Antibody [C8/1779R]

IgG, k

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.

Recombinant

Protein G affinity chromatography

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Recombinant full-length human CD8a protein was used as immunogen for this recombinant CD8 antibody.

CD8a molecule

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.