Recombinant PMEL17 / Melanoma gp100 Antibody [PMEL/1825R]

IgG, k

Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.

Cytotoxic T lymphocytes (CTL's) recognize melanoma-associated antigens, which belong to three main groups. These groups include tumor-associated testis-specific antigens, melanocyte differentiation antigens and mutated or aberrantly expressed antigens, which are routinely used as markers to identify melanomas based on their binding to specific monoclonal antibodies. gp100, also designated ME20-M, ME20-S and PMEL 17, is classified as a melanocyte differentiation antigen and is expressed at low levels in normal cell lines and tissues, but is upregulated in melanocytes. gp100 is a highly glycosylated protein. It is also the product of proteolytic cleavage, which results in a secreted protein.

0.2 mg/mL

Recombinant human protein was used as the immunogen for the recombinant gp100 antibody.

premelanosome protein

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.