TL1A Antibody [TLRM1-1]

IgG 1, kappa

Aliquot and Store at 2-8°C. Avoid freez-thaw cycles.

TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.

0.2 mg/mL

A human partial recombinant protein was used as the immunogen for this TL1A antibody.

tumor necrosis factor (ligand) superfamily, member 15

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.