Recombinant Parathyroid Hormone Antibody [PTH/1717R]

IgG, kappa

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

PTH/Parathyroid hormone is a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Recombinant

Protein A affinity chromatography

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

A synthetic peptide from the N-terminal region of human Parathyroid hormone was used as the immunogen for the recombinant PTH antibody.

Parathyroid hormone

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.