LTbetaR Antibody [4H8 WH2] (preservative free)

Functional Application: Agonist inducing BAFF, chemokines and integrins in vitro and in vivo.

Stable for at least 1 year after receipt when stored at -20°C.

The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

>95% (SDS-PAGE)

Liquid. In PBS containing 10% glycerol. Preservative free formulation.

Monoclonal

Mus musculus