NLRP6/NALP6 Antibody [Clint-1]

Primary Antibodies

Stable for at least 1 year after receipt when stored at -20˚ C.

The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

None

>95% (SDS-PAGE)

Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.

Recognizes human NLRP6.

Monoclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.