Caspase-11 Antibody [4E11]

Primary Antibodies

Stable for at least 1 year after receipt when stored at -20˚ C.

Caspase-11 not only activates caspase-1, that is required for the maturation of proinflammatory cytokines such as interleukin-1 (IL-1) and interleukin-18 (IL-18), but also activates caspase-3, leading to cellular apoptosis under pathological conditions. In most cells, caspase-11 is only expressed upon induction with pro-inflammatory stimuli. Caspase-11 is an essential mediator of endotoxic shock and caspase-11-deficient mice are resistant to endotoxic shock. LPS-induced caspase-11 regulates lymphocyte apoptosis by activating both caspase-3 and caspase-7.

None

>95% (SDS-PAGE)

Liquid. In PBS containing 0.02% sodium azide.

Recognizes mouse and rat full-length caspase-11 protein. Detects two bands of ~38kDa and ~43kDa by Western blot.

Monoclonal

Mus musculus

Optimal dilutions for each application to be determined by the researcher.