MME Antibody

Primary Antibodies

Blue Ice

86 kDa

This gene encodes a common acute lymphocytic leukemia
antigen that is an important cell surface marker in the diagnosis
of human acute lymphocytic leukemia (ALL). This protein is present
on leukemic cells of pre-B phenotype, which represent 85% of cases
of ALL. This protein is not restricted to leukemic cells, however,
and is found on a variety of normal tissues. It is a glycoprotein
that is particularly abundant in kidney, where it is present on the
brush border of proximal tubules and on glomerular epithelium. The
protein is a neutral endopeptidase that cleaves peptides at the
amino side of hydrophobic residues and inactivates several peptide
hormones including glucagon, enkephalins, substance P, neurotensin,
oxytocin, and bradykinin. This gene, which encodes a 100-kD type II
transmembrane glycoprotein, exists in a single copy of greater than
45 kb. The 5' untranslated region of this gene is alternatively
spliced, resulting in four separate mRNA transcripts. The coding
region is not affected by alternative splicing. [provided by
RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This MME antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-747 amino acids from the C-terminal region of human MME.

Neprilysin

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.