CD130 Antibody

Primary Antibodies

Blue Ice

104 kDa

The protein encoded by this gene is a signal transducer
shared by many cytokines, including interleukin 6 (IL6), ciliary
neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and
oncostatin M (OSM). This protein functions as a part of the
cytokine receptor complex. The activation of this protein is
dependent upon the binding of cytokines to their receptors. vIL6, a
protein related to IL6 and encoded by the Kaposi sarcoma-associated
herpesvirus, can bypass the interleukin 6 receptor (IL6R) and
directly activate this protein. Knockout studies in mice suggest
that this gene plays a critical role in regulating myocyte
apoptosis. Alternatively spliced transcript variants encoding
distinct isoforms have been described. A related pseudogene has
been identified on chromosome 17.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This CD130 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 871-899 amino acids from the C-terminal region of human CD130.

Interleukin-6 receptor subunit beta

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.