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CD130 Antibody

CD130 Antibody

Item no.	PRS-55-632-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Blastoma Carcinoma Cell Biology Cell Status Immunohistochemistry Western Blot Proliferation Primary Antibodies By Organ Bladder Cancer Glial Cell Markers
Type	Antibody Polyclonal
Format	Liquid
Applications	WB, IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Goette, N.P., et al. Exp. Hematol. 38(10):868-876(2010) Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) : Olsen, J.V., et al. Cell 127(3):635-648(2006)
NCBI	IL6ST
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Interleukin-6 receptor subunit beta, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6R-beta, IL-6RB, CDw130, Interleukin-6 signal transducer, Membrane glycoprotein 130, gp130, Oncostatin-M receptor subunit alpha, CD130, IL6ST
Available
Manufacturer - Applications	For WB starting dilution is: 1:2000 For IHC-P starting dilution is: 1:25
Manufacturer - Isotype	Rabbit Ig
Shipping Temperature	blue ice or room temperature
Storage Conditions	Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	104 kDa
Manufacturer - Research Area	Cancer, Cell Cycle, Immunology, Signal Transduction
Background	The protein encoded by this gene is a signal transducershared by many cytokines, including interleukin 6 (IL6), ciliaryneurotrophic factor (CNTF), leukemia inhibitory factor (LIF), andoncostatin M (OSM). This protein functions as a part of thecytokine receptor complex. The activation of this protein isdependent upon the binding of cytokines to their receptors. vIL6, aprotein related to IL6 and encoded by the Kaposi sarcoma-associatedherpesvirus, can bypass the interleukin 6 receptor (IL6R) anddirectly activate this protein. Knockout studies in mice suggestthat this gene plays a critical role in regulating myocyteapoptosis. Alternatively spliced transcript variants encodingdistinct isoforms have been described. A related pseudogene hasbeen identified on chromosome 17.
Protein Gi #	215273999
Purification	This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration	Batch dependent
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Immunogen	This CD130 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 871-899 amino acids from the C-terminal region of human CD130.
Clonality	Polyclonal
NCBI Official Name	Interleukin-6 receptor subunit beta
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 11/6/2025

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