EDN3 Antibody

Primary Antibodies

Blue Ice

25 kDa

The protein encoded by this gene is a member of the
endothelin family. Endothelins are endothelium-derived vasoactive
peptides involved in a variety of biological functions. The active
form of this protein is a 21 amino acid peptide processed from the
precursor protein. The active peptide is a ligand for endothelin
receptor type B (EDNRB). The interaction of this endothelin with
EDNRB is essential for development of neural crest-derived cell
lineages, such as melanocytes and enteric neurons. Mutations in
this gene and EDNRB have been associated with Hirschsprung disease
(HSCR) and Waardenburg syndrome (WS), which are congenital
disorders involving neural crest-derived cells. Four alternatively
spliced transcript variants encoding three distinct isoforms have
been observed.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This EDN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 168-197 amino acids from the C-terminal region of human EDN3.

Endothelin-3

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.