CTNB1 Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

For IF starting dilution is: 1:10~50

blue ice or room temperature

85 kDa

The protein encoded by this gene is part of a complex ofproteins that constitute adherens junctions (AJs). AJs arenecessary for the creation and maintenance of epithelial celllayers by regulating cell growth and adhesion between cells. Theencoded protein also anchors the actin cytoskeleton and may beresponsible for transmitting the contact inhibition signal thatcauses cells to stop dividing once the epithelial sheet iscomplete. Finally, this protein binds to the product of the APCgene, which is mutated in adenomatous polyposis of the colon.Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer.Three transcript variants encoding the same protein have been foundfor this gene.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This CTNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 646-673 amino acids from the C-terminal region of human CTNB1.

Catenin beta-1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.