F11 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

This gene encodes coagulation factor XI of the blood
coagulation cascade. This protein is present in plasma as a
zymogen, which is a unique plasma coagulation enzyme because it
exists as a homodimer consisting of two identical polypeptide
chains linked by disulfide bonds. During activation of the plasma
factor XI, an internal peptide bond is cleaved by factor XIIa (or
XII) in each of the two chains, resulting in activated factor XIa,
a serine protease composed of two heavy and two light chains held
together by disulfide bonds. This activated plasma factor XI
triggers the middle phase of the intrisic pathway of blood
coagulation by activating factor IX. Defects in this factor lead to
Rosenthal syndrome, a blood coagulation abnormality. [provided by
RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This F11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-307 amino acids from the Central region of human F11.

Coagulation factor XI

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.