PAX5 Antibody

Primary Antibodies

Blue Ice

42 kDa

This gene encodes a member of the paired box (PAX) family
of transcription factors. The central feature of this gene family
is a novel, highly conserved DNA-binding motif, known as the paired
box. PAX proteins are important regulators in early development,
and alterations in the expression of their genes are thought to
contribute to neoplastic transformation. This gene encodes the
B-cell lineage specific activator protein that is expressed at
early, but not late stages of B-cell differentiation. Its
expression has also been detected in developing CNS and testis and
so the encoded protein may also play a role in neural development
and spermatogenesis. This gene is located at 9p13, which is
involved in t(9; 14)(p13; q32) translocations recurring in small
lymphocytic lymphomas of the plasmacytoid subtype, and in derived
large-cell lymphomas. This translocation brings the potent E-mu
enhancer of the IgH gene into close proximity of the PAX5 promoter,
suggesting that the deregulation of transcription of this gene
contributes to the pathogenesis of these lymphomas. Alternatively
spliced transcript variants encoding different isoforms have been
described but their biological validity has not been determined.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Mouse

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.