PTPRC Antibody

Primary Antibodies

Blue Ice

147 kDa

The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. PTPs are known to be
signaling molecules that regulate a variety of cellular processes
including cell growth, differentiation, mitotic cycle, and
oncogenic transformation. This PTP contains an extracellular
domain, a single transmembrane segment and two tandem
intracytoplasmic catalytic domains, and thus belongs to receptor
type PTP. This gene is specifically expressed in hematopoietic
cells. This PTP has been shown to be an essential regulator of T-
and B-cell antigen receptor signaling. It functions through either
direct interaction with components of the antigen receptor
complexes, or by activating various Src family kinases required for
the antigen receptor signaling. This PTP also suppresses JAK
kinases, and thus functions as a regulator of cytokine receptor
signaling. Four alternatively spliced transcripts variants of this
gene, which encode distinct isoforms, have been reported. [provided
by RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This PTPRC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the N-terminal region of human PTPRC.

Receptor-type tyrosine-protein phosphatase C

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.