PCDHGA8 Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

For IF starting dilution is: 1:10~50

blue ice or room temperature

101 kDa

This gene is a member of the protocadherin gamma genecluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-likeorganization, suggesting that a novel mechanism may be involved intheir regulation and expression. The gamma gene cluster includes 22genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the moredistantly related subfamily C contains 3 genes. The tandem array of22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Eachvariable region exon encodes the extracellular region, whichincludes 6 cadherin ectodomains and a transmembrane region. Theconstant region exons encode the common cytoplasmic region. Theseneural cadherin-like cell adhesion proteins most likely play acritical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beendescribed for the gamma cluster genes.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Polyclonal

Homo sapiens