TGIF1 Antibody

Primary Antibodies

Blue Ice

43 kDa

The protein encoded by this gene is a member of the
three-amino acid loop extension (TALE) superclass of atypical
homeodomains. TALE homeobox proteins are highly conserved
transcription regulators. This particular homeodomain binds to a
previously characterized retinoid X receptor responsive element
from the cellular retinol-binding protein II promoter. In addition
to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha
transcription activation of the retinoic acid responsive element,
the protein is an active transcriptional co-repressor of SMAD2 and
may participate in the transmission of nuclear signals during
development and in the adult. Mutations in this gene are associated
with holoprosencephaly type 4, which is a structural anomaly of the
brain. Alternative splicing has been observed at this locus and
eight variants, encoding four distinct isoforms, are described.

None

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Chicken

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.