ABCD2 Antibody

Primary Antibodies

Blue Ice

83 kDa

The protein encoded by this gene is a member of the
superfamily of ATP-binding cassette (ABC) transporters. ABC
proteins transport various molecules across extra- and
intra-cellular membranes. ABC genes are divided into seven distinct
subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
protein is a member of the ALD subfamily, which is involved in
peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
organelle. All known peroxisomal ABC transporters are half
transporters which require a partner half transporter molecule to
form a functional homodimeric or heterodimeric transporter. The
function of this peroxisomal membrane protein is unknown; however
this protein is speculated to function as a dimerization partner of
ABCD1 and/or other peroxisomal ABC transporters. Mutations in this
gene have been observed in patients with adrenoleukodystrophy, a
severe demyelinating disease. This gene has been identified as a
candidate for a modifier gene, accounting for the extreme variation
among adrenoleukodystrophy phenotypes. This gene is also a
candidate for a complement group of Zellweger syndrome, a
genetically heterogeneous disorder of peroxisomal biogenesis.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ABCD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human ABCD2.

ATP-binding cassette sub-family D member 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.