PTPN2 Antibody

Primary Antibodies

Blue Ice

48 kDa

The protein encoded by this gene is a member of the
protein tyrosine phosphatase (PTP) family. Members of the PTP
family share a highly conserved catalytic motif, which is essential
for the catalytic activity. PTPs are known to be signaling
molecules that regulate a variety of cellular processes including
cell growth, differentiation, mitotic cycle, and oncogenic
transformation. Epidermal growth factor receptor and the adaptor
protein Shc were reported to be substrates of this PTP, which
suggested the roles in growth factor mediated cell signaling. Three
alternatively spliced variants of this gene, which encode isoforms
differing at their extreme C-termini, have been described. The
different C-termini are thought to determine the substrate
specificity, as well as the cellular localization of the isoforms.
Two highly related but distinctly processed pseudogenes that
localize to distinct chromosomes have been reported. [provided by
RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This PTPN2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 329-358 amino acids from the C-terminal region of human PTPN2.

Tyrosine-protein phosphatase non-receptor type 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.