PTPN2 Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

blue ice or room temperature

48 kDa

The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. Members of the PTPfamily share a highly conserved catalytic motif, which is essentialfor the catalytic activity. PTPs are known to be signalingmolecules that regulate a variety of cellular processes includingcell growth, differentiation, mitotic cycle, and oncogenictransformation. Epidermal growth factor receptor and the adaptorprotein Shc were reported to be substrates of this PTP, whichsuggested the roles in growth factor mediated cell signaling. Threealternatively spliced variants of this gene, which encode isoformsdiffering at their extreme C-termini, have been described. Thedifferent C-termini are thought to determine the substratespecificity, as well as the cellular localization of the isoforms.Two highly related but distinctly processed pseudogenes thatlocalize to distinct chromosomes have been reported. [provided byRefSeq].

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Polyclonal

Homo sapiens