HLA-DRB4 Antibody

Primary Antibodies

Blue Ice

30 kDa

HLA-DRB4 belongs to the HLA class II beta chain
paralogues. This class II molecule is a heterodimer consisting of
an alpha (DRA) and a beta (DRB) chain, both anchored in the
membrane. It plays a central role in the immune system by
presenting peptides derived from extracellular proteins. Class II
molecules are expressed in antigen presenting cells (APC: B
lymphocytes, dendritic cells, macrophages). The beta chain is
approximately 26-28 kDa and its gene contains 6 exons. Exon one
encodes the leader peptide, exons 2 and 3 encode the two
extracellular domains, exon 4 encodes the transmembrane domain and
exon 5 encodes the cytoplasmic tail. Within the DR molecule the
beta chain contains all the polymorphisms specifying the peptide
binding specificities. Typing for these polymorphisms is routinely
done for bone marrow and kidney transplantation. DRB1 is expressed
at a level five times higher than its paralogues DRB3, DRB4 and
DRB5. The presence of DRB4 is linked with allelic variants of DRB1,
otherwise it is omitted. There are 4 related pseudogenes: DRB2,
DRB6, DRB7, DRB8 and DRB9.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This HLA-DRB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-72 amino acids from the N-terminal region of human HLA-DRB4.

HLA class II histocompatibility antigen, DR beta 4 chain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.