GRM1 Antibody

Primary Antibodies

Blue Ice

132 kDa

L-glutamate is the major excitatory neurotransmitter in
the central nervous system and activates both ionotropic and
metabotropic glutamate receptors. Glutamatergic neurotransmission
is involved in most aspects of normal brain function and can be
perturbed in many neuropathologic conditions. The metabotropic
glutamate receptors are a family of G protein-coupled receptors,
that have been divided into 3 groups on the basis of sequence
homology, putative signal transduction mechanisms, and
pharmacologic properties. Group I includes GRM1 and GRM5 and these
receptors have been shown to activate phospholipase C. Group II
includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7
and GRM8. Group II and III receptors are linked to the inhibition
of the cyclic AMP cascade but differ in their agonist
selectivities. The canonical alpha isoform of the metabotropic
glutamate receptor 1 gene is a disulfide-linked homodimer whose
activity is mediated by a G-protein-coupled
phosphatidylinositol-calcium second messenger system. Alternative
splicing results in multiple transcript variants encoding distinct
isoforms; some of which may have distinct functions. [provided by
RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This GRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1095-1123 amino acids from the C-terminal region of human GRM1.

Metabotropic glutamate receptor 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.