MMP8 Antibody

Primary Antibodies

Blue Ice

53 kDa

Proteins of the matrix metalloproteinase (MMP) family are
involved in the breakdown of extracellular matrix in normal
physiological processes, such as embryonic development,
reproduction, and tissue remodeling, as well as in disease
processes, such as arthritis and metastasis. Most MMP's are
secreted as inactive proproteins which are activated when cleaved
by extracellular proteinases. However, the enzyme encoded by this
gene is stored in secondary granules within neutrophils and is
activated by autolytic cleavage. Its function is degradation of
type I, II and III collagens. The gene is part of a cluster of MMP
genes which localize to chromosome 11q22.3.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This MMP8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 56-84 amino acids from the N-terminal region of human MMP8.

Neutrophil collagenase

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.