POF1B Antibody

Primary Antibodies

Blue Ice

68 kDa

Premature ovarian failure (POF) is characterized by
primary or secondary amenorrhea in women less than 40 years old.
Two POF susceptibility regions called 'POF1' and 'POF2' have been
identified by breakpoint mapping of X-autosome translocations. POF1
extends from Xq21-qter while POF2 extends from Xq13.3 to Xq21.1.
This gene, POF1B, resides in the POF2 region. This gene is
expressed at trace levels in mouse prenatal ovary and is barely
detectable or absent from adult ovary, in human and in the mouse
respectively. This gene's expression is restricted to epithelia
with its highest expression in the epidermis, and oro-pharyngeal
and gastro-intestinal tracts. The protein encoded by this gene
binds non-muscle actin filaments. The role this gene may play in
the etiology of premature ovarian failure remains to be determined.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This POF1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 337-366 amino acids from the Central region of human POF1B.

Protein POF1B

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.