RFX5 Antibody

Primary Antibodies

Blue Ice

65 kDa

A lack of MHC-II expression results in a severe
immunodeficiency syndrome called MHC-II deficiency, or the bare
lymphocyte syndrome (BLS; MIM 209920). At least 4 complementation
groups have been identified in B-cell lines established from
patients with BLS. The molecular defects in complementation groups
B, C, and D all lead to a deficiency in RFX, a nuclear protein
complex that binds to the X box of MHC-II promoters. The lack of
RFX binding activity in complementation group C results from
mutations in the RFX5 gene encoding the 75-kD subunit of RFX
(Steimle et al., 1995). RFX5 is the fifth member of the growing
family of DNA-binding proteins sharing a novel and highly
characteristic DNA-binding domain called the RFX motif. Multiple
alternatively spliced transcript variants have been found but the
full-length natures of only two have been determined. [provided by
RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This RFX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human RFX5.

DNA-binding protein RFX5

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.