PITX2 Antibody

Primary Antibodies

Blue Ice

35 kDa

This gene encodes a member of the RIEG/PITX homeobox
family, which is in the bicoid class of homeodomain proteins. The
encoded protein acts as a transcription factor and regulates
procollagen lysyl hydroxylase gene expression. This protein plays a
role in the terminal differentiation of somatotroph and lactotroph
cell phenotypes, is involved in the development of the eye, tooth
and abdominal organs, and acts as a transcriptional regulator
involved in basal and hormone-regulated activity of prolactin.
Mutations in this gene are associated with Axenfeld-Rieger
syndrome, iridogoniodysgenesis syndrome, and sporadic cases of
Peters anomaly. A similar protein in other vertebrates is involved
in the determination of left-right asymmetry during development.
Alternatively spliced transcript variants encoding distinct
isoforms have been described.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This PITX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 42-71 amino acids from the N-terminal region of human PITX2.

Pituitary homeobox 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.