PPM1A Antibody

Primary Antibodies

Blue Ice

42 kDa

The protein encoded by this gene is a member of the PP2C
family of Ser/Thr protein phosphatases. PP2C family members are
known to be negative regulators of cell stress response pathways.
This phosphatase dephosphorylates, and negatively regulates the
activities of, MAP kinases and MAP kinase kinases. It has been
shown to inhibit the activation of p38 and JNK kinase cascades
induced by environmental stresses. This phosphatase can also
dephosphorylate cyclin-dependent kinases, and thus may be involved
in cell cycle control. Overexpression of this phosphatase is
reported to activate the expression of the tumor suppressor gene
TP53/p53, which leads to G2/M cell cycle arrest and apoptosis.
Three alternatively spliced transcript variants encoding distinct
isoforms have been described.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Bovine, Rabbit

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.