PUF60 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

The protein encoded by this gene is a Ro RNP-binding
protein. It interacts with Ro RNPs and their interaction is thought
to represent a gain of function for Ro RNPs. This protein also
forms a ternary complex with far upstream element (FUSE) and
FUSE-binding protein. It can repress a c-myc reporter via the FUSE.
It is also known to target transcription factor IIH and inhibit
activated transcription. This gene is implicated in the xeroderma
pigmentosum disorder. There are two alternatively spliced
transcript variants of this gene encoding different isoforms. There
seems to be evidence of multiple polyadenylation sites for this
gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This PUF60 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-43 amino acids from the N-terminal region of human PUF60.

Poly(U)-binding-splicing factor PUF60

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.