MCM4 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

The protein encoded by this gene is one of the highly
conserved mini-chromosome maintenance proteins (MCM) that are
essential for the initiation of eukaryotic genome replication. The
hexameric protein complex formed by MCM proteins is a key component
of the pre-replication complex (pre_RC) and may be involved in the
formation of replication forks and in the recruitment of other DNA
replication related proteins. The MCM complex consisting of this
protein and MCM2, 6 and 7 proteins possesses DNA helicase activity,
and may act as a DNA unwinding enzyme. The phosphorylation of this
protein by CDC2 kinase reduces the DNA helicase activity and
chromatin binding of the MCM complex. This gene is mapped to a
region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a
DNA-activated protein kinase involved in the repair of DNA
double-strand breaks. Alternatively spliced transcript variants
encoding the same protein have been reported.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Xenopus, Mouse

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.