NR1I3 Antibody

Primary Antibodies

Blue Ice

40 kDa

This gene encodes a member of the nuclear receptor
superfamily, and is a key regulator of xenobiotic and endobiotic
metabolism. The protein binds to DNA as a monomer or a heterodimer
with the retinoid X receptor and regulates the transcription of
target genes involved in drug metabolism and bilirubin clearance,
such as cytochrome P450 family members. Unlike most nuclear
receptors, this transcriptional regulator is constitutively active
in the absence of ligand but is regulated by both agonists and
inverse agonists. Ligand binding results in translocation of this
protein to the nucleus, where it activates or represses target gene
transcription. These ligands include bilirubin, a variety of
foreign compounds, steroid hormones, and prescription drugs.
Multiple transcript variants encoding different isoforms have been
found for this gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This NR1I3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 155-183 amino acids from the Central region of human NR1I3.

Nuclear receptor subfamily 1 group I member 3

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.