KDELR2 Antibody

Primary Antibodies

Blue Ice

24 kDa

Retention of resident soluble proteins in the lumen of the
endoplasmic reticulum (ER) is achieved in both yeast and animal
cells by their continual retrieval from the cis-Golgi, or a
pre-Golgi compartment. Sorting of these proteins is dependent on a
C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in
animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This
process is mediated by a receptor that recognizes, and binds the
tetrapeptide-containing protein, and returns it to the ER. In
yeast, the sorting receptor encoded by a single gene, ERD2, is a
seven-transmembrane protein. Unlike yeast, several human homologs
of the ERD2 gene, constituting the KDEL receptor gene family, have
been described. KDELR2 was the second member of the family to be
identified, and it encodes a protein which is 83% identical to the
KDELR1 gene product. Alternative splicing results in multiple
transcript variants encoding distinct isoforms. [provided by
RefSeq].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Xenopus, Bovine, Mouse, Rat

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.