C4BPB Antibody

Primary Antibodies

Blue Ice

28 kDa

This gene encodes a member of a superfamily of proteins
composed predominantly of tandemly arrayed short consensus repeats
of approximately 60 amino acids. A single, unique beta-chain
encoded by this gene assembles with seven identical alpha-chains
into the predominant isoform of C4b-binding protein, a multimeric
protein that controls activation of the complement cascade through
the classical pathway. C4b-binding protein has a regulatory role in
the coagulation system also, mediated through the beta-chain
binding of protein S, a vitamin K-dependent protein that serves as
a cofactor of activated protein C. The genes encoding both alpha
and beta chains are located adjacent to each other on human
chromosome 1 in the regulator of complement activation gene
cluster. Alternative splicing gives rise to multiple transcript
variants.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This C4BPB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 125-153 amino acids from the Central region of human C4BPB.

C4b-binding protein beta chain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.