ARNT2 Antibody

For WB starting dilution is: 1:1000

For IF starting dilution is: 1:10~50

blue ice or room temperature

79 kDa

This gene encodes a member of thebasic-helix-loop-helix-Per-Arnt-Sim (bHLH-PAS) superfamily oftranscription factors. The encoded protein acts as a partner forseveral sensor proteins of the bHLH-PAS family, formingheterodimers with the sensor proteins that bind regulatory DNAsequences in genes responsive to developmental and environmentalstimuli. Under hypoxic conditions, the encoded protein complexeswith hypoxia-inducible factor 1alpha in the nucleus and thiscomplex binds to hypoxia-responsive elements in enhancers andpromoters of oxygen-responsive genes. A highly similar protein inmouse forms functional complexes with both aryl hydrocarbonreceptors and Single-minded proteins, suggesting addition roles forthe encoded protein in the metabolism of xenobiotic compounds andthe regulation of neurogenesis, respectively.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ARNT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 249-278 amino acids from the Central region of human ARNT2.

Aryl hydrocarbon receptor nuclear translocator 2

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.