SOST Antibody

For WB starting dilution is: 1:500

blue ice or room temperature

24 kDa

Sclerostin is a secreted glycoprotein with a C-terminalcysteine knot-like (CTCK) domain and sequence similarity to the DAN(differential screening-selected gene aberrative in neuroblastoma)family of bone morphogenetic protein (BMP) antagonists.Loss-of-function mutations in this gene are associated with anautosomal-recessive disorder, sclerosteosis, which causesprogressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with amilder form of the disorder called van Buchem disease. [provided byRefSeq].

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.

Sclerostin

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.