Mouse Rnasel Antibody

For WB starting dilution is: 1:1000

blue ice or room temperature

83 kDa

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity).

Batch dependent

This Mouse Rnasel antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-167 amino acids from the N-terminal region of mouse Rnasel.

2-5A-dependent ribonuclease

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.