FIG4 Antibody

Neuroscience, Signal Transduction

For WB starting dilution is: 1:1000

This antibody is purified through a protein A column, followed by peptide affinity purification.

Rabbit Ig

Supplied in PBS with 0.09% (W/V) sodium azide.

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

None

Q92562

9896

FIG4

Homo sapiens

The protein encoded by this gene belongs to the SACdomain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of sevenconserved motifs, has been shown to possess phosphoinositidephosphatase activity. The yeast homolog, Sac1p, is involved in theregulation of various phosphoinositides, and affects diversecellular functions such as actin cytoskeleton organization, Golgifunction, and maintenance of vacuole morphology. Membrane-boundphosphoinositides function as signaling molecules and play a keyrole in vesicle trafficking in eukaryotic cells. Mutations in thisgene have been associated with Charcot-Marie-Tooth disease, type4J.

Tsai, C.P., et al. Neurobiol. Aging (2010) In press :

Soranzo, N., et al. Nat. Genet. 41(11):1182-1190(2009)

Western blot analysis in mouse kidney tissue lysates (35ug/lane).