FIG4 Antibody

Primary Antibodies

Blue Ice

104 kDa

The protein encoded by this gene belongs to the SAC
domain-containing protein gene family. The SAC domain,
approximately 400 amino acids in length and consisting of seven
conserved motifs, has been shown to possess phosphoinositide
phosphatase activity. The yeast homolog, Sac1p, is involved in the
regulation of various phosphoinositides, and affects diverse
cellular functions such as actin cytoskeleton organization, Golgi
function, and maintenance of vacuole morphology. Membrane-bound
phosphoinositides function as signaling molecules and play a key
role in vesicle trafficking in eukaryotic cells. Mutations in this
gene have been associated with Charcot-Marie-Tooth disease, type
4J.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This FIG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 846-874 amino acids from the C-terminal region of human FIG4.

Polyphosphoinositide phosphatase

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.