ACER1 Antibody

Primary Antibodies

Blue Ice

31 kDa

Ceramides are synthesized during epidermal differentiation
and accumulate within the interstices of the stratum corneum, where
they represent critical components of the epidermal permeability
barrier. Excess cellular ceramide can trigger antimitogenic signals
and induce apoptosis, and the ceramide metabolites sphingosine and
sphingosine-1-phosphate (S1P) are important bioregulatory
molecules. Ceramide hydrolysis in the nucleated cell layers
regulates keratinocyte proliferation and apoptosis in response to
external stress. Ceramide hydrolysis also occurs at the stratum
corneum, releasing free sphingoid base that functions as an
endogenous antimicrobial agent. ACER1 is highly expressed in
epidermis and catalyzes the hydrolysis of very long chain ceramides
to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun
et al., 2008 [PubMed 17713573]).

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ACER1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 236-263 amino acids from the C-terminal region of human ACER1.

Alkaline ceramidase 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.