AKTIP Antibody

Primary Antibodies

Blue Ice

33 kDa

The mouse homolog of this gene produces fused toes and
thymic hyperplasia in heterozygous mutant animals while homozygous
mutants die in early development. This gene may play a role in
apoptosis as these morphological abnormalities are caused by
altered patterns of programmed cell death. The protein encoded by
this gene is similar to the ubiquitin ligase domain of other
ubiquitin-conjugating enzymes but lacks the conserved cysteine
residue that enables those enzymes to conjugate ubiquitin to the
target protein. This protein interacts directly with
serine/threonine kinase protein kinase B (PKB)/Akt and modulates
PKB activity by enhancing the phosphorylation of PKB's regulatory
sites. Alternative splicing results in two transcript variants
encoding the same protein.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse, Rat

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.