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Ataxin3 Antibody

Ataxin3 Antibody

Item no.	PRS-61-135-400ul
Manufacturer	ProSci
Amount	400 ul
Category	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Mesothelioma Immunohistochemistry Autophagy Primary Antibodies
Type	Antibody Polyclonal
Format	Liquid
Applications	IHC-P
Specific against	Human (Homo sapiens)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Albrecht, M., et al., Eur. J. Biochem. 271(15):3155-3170 (2004). Michlewski, G., et al., J. Mol. Biol. 340(4):665-679 (2004). Li, Y., et al., Ann. Neurol. 56(1):124-129 (2004). Beuckmann, C.T., et al., J. Neurosci. 24(18):4469-4477 (2004).
NCBI	ATXN3
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Ataxin-3, Machado-Joseph disease protein 1, Spinocerebellar ataxia type 3 protein, ATXN3, ATX3, MJD, MJD1, SCA3
Available
Manufacturer - Applications	For IHC-P starting dilution is: 1:50~100
Manufacturer - Isotype	Rabbit Ig
Shipping Temperature	blue ice or room temperature
Storage Conditions	Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Molecular Weight	42 kDa
Manufacturer - Research Area	Neuroscience
Background	Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
Protein Gi #	290457685
Purification	This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration	Batch dependent
Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.
Immunogen	This Ataxin3 (MJD) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 29-59 amino acids from the N-terminal region of human Ataxin3 (MJD).
Clonality	Polyclonal
NCBI Official Name	Ataxin-3
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 400 ul

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Delivery expected until 10/2/2025

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