ARHGEF3 Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

blue ice or room temperature

60 kDa

Rho-like GTPases are involved in a variety of cellularprocesses, and they are activated by binding GTP and inactivated byconversion of GTP to GDP by their intrinsic GTPase activity.Guanine nucleotide exchange factors (GEFs) accelerate the GTPaseactivity of Rho GTPases by catalyzing their release of bound GDP.This gene encodes a guanine nucleotide exchange factor, whichspecifically activates two members of the Rho GTPase family: RHOAand RHOB, both of which have a role in bone cell biology. It hasbeen identified that genetic variation in this gene plays a role inthe determination of bone mineral density (BMD), indicating theimplication of this gene in postmenopausal osteoporosis.Alternatively spliced transcript variants encoding differentisoforms have been found for this gene.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ARHGEF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ARHGEF3.

Rho guanine nucleotide exchange factor 3

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.