ARHGEF3 Antibody

Primary Antibodies

Blue Ice

60 kDa

Rho-like GTPases are involved in a variety of cellular
processes, and they are activated by binding GTP and inactivated by
conversion of GTP to GDP by their intrinsic GTPase activity.
Guanine nucleotide exchange factors (GEFs) accelerate the GTPase
activity of Rho GTPases by catalyzing their release of bound GDP.
This gene encodes a guanine nucleotide exchange factor, which
specifically activates two members of the Rho GTPase family: RHOA
and RHOB, both of which have a role in bone cell biology. It has
been identified that genetic variation in this gene plays a role in
the determination of bone mineral density (BMD), indicating the
implication of this gene in postmenopausal osteoporosis.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Chicken, Monkey, Mouse

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.