MMP24 Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

blue ice or room temperature

73 kDa

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MMP24 is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed matrix metalloproteinase 24 (MMP24).

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Supplied in PBS with 0.09% (W/V) sodium azide.

This MMP24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-425 amino acids from the Central region of human MMP24.

Matrix metalloproteinase-24

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.