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CD11c Antibody [N418]

CD11c Antibody [N418]

Item no.	PRS-76-096-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies By Cell Type Hematology Leukemia Cell Biology Cell Movement Cell Adhesion Flow Cytometry Immunohistochemistry Immunoprecipitation Immunofluorescence Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC, IF, IP, IHC
Clone	N418
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Barclay, A. N., Brown, M. H., Law, S. A. K. A., McKnight, A. J., Tomlinson, M. G., van der Merwe, P. A. (1997).The leucocyte antigen factsbook. Academic Press. Pulendran, B., Lingappa, J., Kennedy, M. K., Smith, J., Teepe, M., Rudensky, A., ... Maraskovsky, E. (1997). Developmental pathways of dendritic cells in vivo: distinct function, phenotype, and localization of dendritic cell subsets in FLT3 ligand-treated mice.The Journal of Immunology,159(5), 2222-2231. Xin, K. Q., Mizukami, H., Urabe, M., Toda, Y., Shinoda, K., Yoshida, A., ... Okuda, K. (2006). Induction of robust immune responses against human immunodeficiency virus is supported by the inherent tropism of adeno-associated virus type 5 for dendritic cells.Journal of virology,80(24), 11899-11910.
NCBI	Itgax
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cr4, N418, Cd11c, AI449405, Itgax
Available
Manufacturer - Isotype	Armenian Hamster IgG
Shipping Temperature	blue ice or room temperature
Storage Conditions	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Manufacturer - Research Area	Innate Immunity
Background	The N418 monoclonal antibody specifically reacts with the integrin alphax chain of the mouse CD11c, which is expressed on dendritic cells, CD4-/CD8+ intestinal intraepithelial lymphocytes (IEL) and some activated T lymphocytes. Low levels of CD11c were detected on mouse splenic natural killer cells and on the monocyte/macrophage lineage cells.CD11c expression is upregulated on IEL and T lymphocytes after activation. It binds to CD54, fibrinogen and iC3b and influences the leukocyte adhesive interactions. The N418 antibody binds to CD11c on splenic dendritic cells of the mouse in the T-dependent areas. It also contributes to the binding of iC3b.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration	Batch dependent
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Clonality	Monoclonal
NCBI Official Name	integrin alpha X
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/4/2025

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